AG百家乐大转轮-AG百家乐导航_怎么看百家乐走势_全讯网官网 (中国)·官方网站

Research News

Professor Nan Yao’s team reveals the functions of plant hormone pathways in regulating the sphingolipid metabolism and sphingolipid-related cell death

Source: School of Life Sciences
Edited by: Zheng Longfei, Wang Dongmei

Sphingolipids are a unique subset of primary membrane lipids that exist ubiquitously in eukaryotes. Plant sphingolipids perform critical functions, either as membrane structural components to maintain membrane integrity or as signals and mediators of processes in plant development and response to biological and abiotic stresses. Ceramide is the central component of sphingolipid metabolism, and its content change often affects the homeostasis of sphingolipid metabolism. The accelerated cell death 5 (acd5) mutants of Arabidopsis, which are defective in ceramide kinase, accumulate a large amount of ceramide in the later stage of growth, accompanied by spontaneous cell death phenotype and the increase of salicylic acid (SA) level. In acd5, ceramide-induced cell death depends on SA pathway, but the molecular mechanism underneath and the function of other plant hormones in sphingolipid-related cell death are still unclear.

Professor Nan Yao’s team from the School of Life Sciences at Sun Yat-sen University found that Arabidopsis thaliana lipase-like protein ENHANCED DISEASE SUSCEPTABILITY1 (EDS1) and its partner PHYTOALEXIN DEFINITION4 (PAD4) participate in sphingolipid metabolism and associated cell death (Figure 1). Loss of function of EDS1, PAD4, or SALICYLIC ACID INDUCTION DEFICIENT 2 (SID2) in the acd5 mutant background suppresses the acd5 cell-death phenotype and prevents ceramide accumulation. Several lines of evidence to support the idea that EDS1 and PAD4 contribute to ceramide-mediated SA accumulation and cell death.


Figure 1. The role of EDS1/PAD4 in ceramide-associated cell death

Meanwhile, Prof. Nan Yao’s team also revealed that jasmonate (JA) pathway is involved in mediating sphingolipid metabolism and ceramide-induced cell death (Figure 2). JA induced the accumulations of ceramides and hydroxyceramides which depends on the JA-Ile receptor CORONATINE INSENSITIVE1 (COI1) protein, a key factor of JA signaling pathway. This study found that JA participates in regulating the expression of genes related to ceramide metabolism through the key transcription factor MYC2.


Figure 2. Working model for JA regulation of sphingolipid metabolism and ceramide-associated cell death in acd5.

These works were published in Plant Journal with the title “The immune components EDS1 and PAD4 are required for cell death caused by overaccumulation of ceramides in Arabidopsis” and in Plant Physiology with the title “Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5”. Dr. Hong-Yun Zeng and PhD student Li-Qun Huang are the first authors of the two papers, respectively. Professor Nan Yao is the corresponding author of these two papers. These works are supported by the National Natural Science Foundation of China, the Natural Science Foundation of Guangdong Province and Sun Yat-sen University.

Link to the papers:
https://onlinelibrary.wiley.com/doi/10.1111/tpj.15393
https://doi.org/10.1093/plphys/kiab362
法拉利百家乐官网的玩法技巧和规则| MG百家乐官网大转轮| 大发888什么赢钱快| 百家乐官网视频游戏官网| 定南县| 大发888官网e世博官方网站| 赌场| 澳门百家乐现场视频| 云鼎百家乐官网注册| 百家乐龙虎台布作弊技巧| 广河县| 大上海百家乐的玩法技巧和规则| 网上百家乐官网是叫九五至尊么| 百家乐博娱乐网赌百家乐的玩法技巧和规则 | 博彩业| 百家乐视频游戏金币| 浩博百家乐官网娱乐城| 百家乐正规站| 皇冠走地| 百家乐牌路图表下| 百家乐官网赌场视屏| 盛世国际娱乐城| 百家乐规律和方法| 百家乐官网诀| 百家乐官网压分规律| 大发888官方 黄埔网| 澳门百家乐博客| 网络百家乐官网电脑| 丁青县| 富二代百家乐官网的玩法技巧和规则| 南木林县| 大发888大法8668| 名仕百家乐官网的玩法技巧和规则| 网上博彩业| 百家乐台布21点| 下载百家乐官网的玩法技巧和规则| 百家乐官网什么牌最大| 鑫鼎百家乐的玩法技巧和规则 | 赌场百家乐网站| 百家乐官网有方法赚反水| ewin棋牌官网|